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妹子 [mèi zi] = 妹纸 [mèi zhǐ] n.

Literally “younger sister”, this term is often used by a guy to refer to a girl younger than him. 妹纸 [mèi zhǐ] is a phonetic deviation that mimic the Northeastern accent for comic effects.

一年冬天,有个妹子发烧了,脸红扑扑,她去诊所看,医生一进来用手摸她额头,摸了30秒换另外一只手,然后这破医生说:真暖和。

On a Winter day, a girl got a fever and her face was all red. She went to the clinic. The doctor came in and put his hand on her forehead. 30 seconds later he switched to the other hand. And then, this crazy doctor said, “So warm.”